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Journal of Clinical Microbiology, July 2008, p. 2450-2452, Vol. 46, No. 7
0095-1137/08/$08.00+0     doi:10.1128/JCM.02295-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Severe Thrombocytopenia Associated with Acute Hepatitis E Virus Infection {triangledown}

P. Colson,1,2* E. Payraudeau,1 C. Leonnet,3 S. De Montigny,4 L. Villeneuve,3 A. Motte,1 and C. Tamalet1,2

Laboratoire de Virologie, Fédération Hospitalière de Bactériologie-Virologie Clinique, Centre Hospitalo-Universitaire Timone, 264 Rue Saint-Pierre 13385, Marseille Cedex 05, France,1 URMITE CNRS-IRD UMR 6236, Faculté de Médecine et de Pharmacie, Université de la Méditerranée (Aix-Marseille-II), 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France,2 Laboratoire de Biologie Médicale, Centre Hospitalier d'Aubagne, 179 Avenue des Soeurs Gastine, 13677 Aubagne Cedex, France,3 Service d'Hépato-Gastro-Entérologie, Centre Hospitalier d'Aubagne, 179 Avenue des Soeurs Gastine, 13677 Aubagne Cedex, France4

Received 29 November 2007/ Returned for modification 9 January 2008/ Accepted 1 May 2008

We describe here what is, to the best of our knowledge, the third reported case of severe thrombocytopenia associated with acute hepatitis E virus infection. The patient was a 72-year-old French woman. It seems likely that the cause of the thrombocytopenia was acute hepatitis E virus infection, possibly occurring via an immune mechanism. No complications were noted, in contrast to the two previous reports.

* Corresponding author. Mailing address: Laboratoire de Virologie, Fédération Hospitalière de Bactériologie-Virologie Clinique, Centre Hospitalo-Universitaire Timone, 264 Rue Saint-Pierre 13385, Marseille Cedex 05, France. Phone: 33(0)4 91 38 79 69. Fax: 33(0)4 91 38 55 18. E-mail: philippe.colson{at}ap-hm.fr

{triangledown} Published ahead of print on 14 May 2008.

Journal of Clinical Microbiology, July 2008, p. 2450-2452, Vol. 46, No. 7
0095-1137/08/$08.00+0     doi:10.1128/JCM.02295-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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