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Journal of Clinical Microbiology, September 2008, p. 3124-3126, Vol. 46, No. 9
0095-1137/08/$08.00+0     doi:10.1128/JCM.00592-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Vancomycin Heteroresistance in Bloodstream Isolates of Staphylococcus capitis{triangledown}

Danaë D'mello,1 Andrew J. Daley,2,4 Muhammad Shihab Rahman,1 Yue Qu,1 Suzanne Garland,2,3,4 Christopher Pearce,2 and Margaret A. Deighton1*

School of Applied Sciences, RMIT University, Plenty Road, Bundoora, P.O. Box 71, Victoria 3083, Australia,1 Department of Microbiology, Royal Children's Hospital, Flemington Rd., Parkville, Victoria 3052, Australia,2 Department of Obstetrics and Gynaecology, University of Melbourne, Victoria 3010, Australia,3 Department of Microbiology and Infectious Diseases, Royal Women's Hospital, Victoria, 132 Grattan St., Carlton, Victoria 3053, Australia4

Received 27 March 2008/ Returned for modification 28 May 2008/ Accepted 25 June 2008

Nine Staphylococcus capitis isolates from blood cultures of newborns were examined for resistance to vancomycin. MICs were within the susceptible range, but population profiling revealed a resistant subpopulation. Only isolates with the largest subpopulation were identified as heteroresistant to vancomycin by Etest. This finding may have therapeutic implications.

* Corresponding author. Mailing address: School of Applied Sciences, RMIT University, Plenty Road, Bundoora, PO Box 71, Victoria 3083, Australia. Phone: 61-3-9925 7123. Fax: 61-3-9925 7110. E-mail: m_deighton{at}rmit.edu.au

{triangledown} Published ahead of print on 2 July 2008.

Journal of Clinical Microbiology, September 2008, p. 3124-3126, Vol. 46, No. 9
0095-1137/08/$08.00+0     doi:10.1128/JCM.00592-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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