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Journal of Clinical Microbiology, January 2009, p. 271-274, Vol. 47, No. 1
0095-1137/09/$08.00+0     doi:10.1128/JCM.01478-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Acute Respiratory Failure Involving an R Variant of Mycobacterium abscessus{triangledown}

Emilie Catherinot,1,2 Anne-Laure Roux,1 Edouard Macheras,1 Dominique Hubert,3 Moussa Matmar,4 Luc Dannhoffer,5 Thierry Chinet,5 Philippe Morand,6 Claire Poyart,6 Beate Heym,1 Martin Rottman,1 Jean-Louis Gaillard,1 and Jean-Louis Herrmann1*

Laboratoire de Microbiologie, AP-HP, Hôpital Raymond Poincaré et Hôpital Ambroise Paré, and Université de Versailles-Saint-Quentin-en-Yvelines, EA3647, Garches, France,1 Service de Pneumologie, Hôpital Foch, Suresnes, France,2 Service de Pneumologie, AP-HP, Hôpital Cochin, Paris, France,3 Service de Réanimation Chirurgicale, AP-HP, Hôpital Cochin, Paris, France,4 Laboratoire de Biologie et Pharmacologie des Épithéliums Respiratoires, Université de Versailles-Saint-Quentin-en-Yvelines, UPRES EA 220, Boulogne, France,5 Laboratoire de Microbiologie, AP-HP, Hôpital Cochin, and Institut Cochin, Equipe 44, Paris, France6

Received 1 August 2008/ Returned for modification 27 October 2008/ Accepted 11 November 2008

We report the case of a cystic fibrosis patient colonized with a smooth-morphotype form of Mycobacterium abscessus who developed acute respiratory failure with the emergence of an isogenic rough (R) variant while he was recovering from peritonitis-induced shock. This report emphasizes the role of R forms in severe M. abscessus infections.

* Corresponding author. Mailing address: Service de Microbiologie, Hôpital Raymond Poincaré, 104 Bd. Raymond Poincaré, 92380 Garches, France. Phone: 33 1 47 10 79 50. Fax: 33 1 47 10 79 49. E-mail: jean-louis.herrmann{at}rpc.aphp.fr

{triangledown} Published ahead of print on 19 November 2008.

Journal of Clinical Microbiology, January 2009, p. 271-274, Vol. 47, No. 1
0095-1137/09/$08.00+0     doi:10.1128/JCM.01478-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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