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Journal of Clinical Microbiology, October 2009, p. 3138-3141, Vol. 47, No. 10
0095-1137/09/$08.00+0     doi:10.1128/JCM.01070-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Molecular Identification of Aspergillus Species Collected for the Transplant-Associated Infection Surveillance Network{triangledown}

S. Arunmozhi Balajee,1* Rui Kano,1 John W. Baddley,2,11 Stephen A. Moser,3 Kieren A. Marr,4,5 Barbara D. Alexander,6 David Andes,7 Dimitrios P. Kontoyiannis,8 Giancarlo Perrone,9 Stephen Peterson,10 Mary E. Brandt,1 Peter G. Pappas,2 and Tom Chiller1

Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia,1 Department of Medicine,2 Department of Pathology, University of Alabama at Birmingham,3 Department of Medicine, Birmingham Veterans Affairs Medical Center, Birmingham, Alabama,11 Fred Hutchinson Cancer Research Center, Seattle, Washington,4 Johns Hopkins University, Baltimore, Maryland,5 Duke University, Durham, North Carolina,6 University of Wisconsin, Madison, Wisconsin,7 M. D. Anderson Cancer Center, Houston, Texas,8 Institute of Sciences of Food Production, National Research Council, Bari, Italy,9 National Center for Agricultural Utilization Research, U.S. Department of Agriculture, Peoria, Illinois,10

Received 2 June 2009/ Returned for modification 29 July 2009/ Accepted 3 August 2009

A large aggregate collection of clinical isolates of aspergilli (n = 218) from transplant patients with proven or probable invasive aspergillosis was available from the Transplant-Associated Infection Surveillance Network, a 6-year prospective surveillance study. To determine the Aspergillus species distribution in this collection, isolates were subjected to comparative sequence analyses by use of the internal transcribed spacer and β-tubulin regions. Aspergillus fumigatus was the predominant species recovered, followed by A. flavus and A. niger. Several newly described species were identified, including A. lentulus and A. calidoustus; both species had high in vitro MICs to multiple antifungal drugs. Aspergillus tubingensis, a member of the A. niger species complex, is described from clinical specimens; all A. tubingensis isolates had low in vitro MICs to antifungal drugs.

* Corresponding author. Mailing address: Mycotic Diseases Branch, Centers for Disease Control and Prevention, Mail Stop G 11, 1600 Clifton Road, Atlanta, GA 30333. Phone: (404) 639-3337. Fax: (404) 639-3546. E-mail: fir3{at}cdc.gov

{triangledown} Published ahead of print on 12 August 2009.

Journal of Clinical Microbiology, October 2009, p. 3138-3141, Vol. 47, No. 10
0095-1137/09/$08.00+0     doi:10.1128/JCM.01070-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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