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Journal of Clinical Microbiology, October 2009, p. 3185-3190, Vol. 47, No. 10
0095-1137/09/$08.00+0     doi:10.1128/JCM.00946-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Variation in Susceptibility of Bloodstream Isolates of Candida glabrata to Fluconazole According to Patient Age and Geographic Location in the United States in 2001 to 2007{triangledown}

M. A. Pfaller,1,3* S. A. Messer,1 R. J. Hollis,1 L. Boyken,1 S. Tendolkar,1 J. Kroeger,1 and D. J. Diekema1,2

Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242,1 Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242,2 Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa 522423

Received 12 May 2009/ Returned for modification 18 July 2009/ Accepted 29 July 2009

We examined the susceptibilities to fluconazole of 642 bloodstream infection (BSI) isolates of Candida glabrata and grouped the isolates by patient age and geographic location within the United States. Susceptibility of C. glabrata to fluconazole was lowest in the northeast region (46%) and was highest in the west (76%). The frequencies of isolation and of fluconazole resistance among C. glabrata BSI isolates were higher in the present study (years 2001 to 2007) than in a previous study conducted from 1992 to 2001. Whereas the frequency of C. glabrata increased with patient age, the rate of fluconazole resistance declined. The oldest age group (≥80 years) had the highest proportion of BSI isolates that were C. glabrata (32%) and the lowest rate of fluconazole resistance (5%).

* Corresponding author. Mailing address: Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242. Phone: (319) 356-8615. Fax: (319) 356-4916. E-mail: michael-pfaller{at}uiowa.edu

{triangledown} Published ahead of print on 5 August 2009.

Journal of Clinical Microbiology, October 2009, p. 3185-3190, Vol. 47, No. 10
0095-1137/09/$08.00+0     doi:10.1128/JCM.00946-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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