This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Ishikawa, Y.
Right arrow Articles by Ito, A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ishikawa, Y.
Right arrow Articles by Ito, A.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, October 2009, p. 3191-3196, Vol. 47, No. 10
0095-1137/09/$08.00+0     doi:10.1128/JCM.01111-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Serological Monitoring of Progression of Alveolar Echinococcosis with Multiorgan Involvement by Use of Recombinant Em18{triangledown}

Yuji Ishikawa,1,2 Yasuhito Sako,1 Sonoyo Itoh,1 Takaaki Ohtake,2 Yutaka Kohgo,2 Takeo Matsuno,3 Yoshinobu Ohsaki,4 Naoyuki Miyokawa,5 Minoru Nakao,1 Kazuhiro Nakaya,1,6 and Akira Ito1*

Department of Parasitology,1 Department of Internal Medicine,2 Department of Orthopedic Surgery,3 Respiratory Center,4 Department of Surgical Pathology,5 Animal Laboratory for Medical Research, Asahikawa Medical College, Midorigaoka Higashi 2-1-1-1, Asahikawa 078-8510, Japan6

Received 8 June 2009/ Returned for modification 8 July 2009/ Accepted 13 July 2009

Two cases of alveolar echinococcosis (AE) with multiple-organ involvement (the liver, lungs, and bone) were monitored by imaging and serology for 20 years. Resection of the bone lesion was complete in one case but incomplete in the other case. Albendazole treatment was markedly to moderately effective against hepatic and pulmonary AE lesions in both cases, whereas it had almost no effect against the bone lesion in one case. The results of the serological tests with recombinant Em18 antigen coincided with the clinical findings in each case. An enzyme-linked immunosorbent assay for the detection of immunoglobulin G (IgG) responses, especially IgG4 responses, is expected to be a real-time indicator of the dynamics of active AE.

* Corresponding author. Mailing address: Department of Parasitology, Asahikawa Medical College, Midorigaoka Higashi 2-1-1-1, Asahikawa, 078-8510 Hokkaido, Japan. Phone: 81-166-68-2420. Fax: 81-166-68-2429. E-mail: akiraito{at}asahikawa-med.ac.jp

{triangledown} Published ahead of print on 5 August 2009.

Journal of Clinical Microbiology, October 2009, p. 3191-3196, Vol. 47, No. 10
0095-1137/09/$08.00+0     doi:10.1128/JCM.01111-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»