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Journal of Clinical Microbiology, October 2009, p. 3241-3245, Vol. 47, No. 10
0095-1137/09/$08.00+0     doi:10.1128/JCM.00293-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

homB Status of Helicobacter pylori as a Novel Marker To Distinguish Gastric Cancer from Duodenal Ulcer{triangledown}

Sung Woo Jung,1,2 Mitsushige Sugimoto,1 David Y. Graham,1 and Yoshio Yamaoka1,3*

Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas,1 Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea,2 Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan3

Received 9 February 2009/ Returned for modification 7 July 2009/ Accepted 18 August 2009

The hom family of Helicobacter pylori outer-membrane proteins, especially the homB gene, has been suggested as a novel virulence factor; however, the clinical association and function of this gene are still unclear. We evaluated the presence of the homA, homB, and cagA genes in 286 strains isolated from patients in the U.S. and Colombian populations (126 with gastritis, 96 with duodenal ulcer, and 64 with gastric cancer) by PCR. The results were compared with the clinical presentation and gastric injury. The prevalence of the homB gene was significantly higher in strains isolated from gastric-cancer patients (71.9%) than in those from duodenal ulcer patients (52.1%) (P = 0.012). In a multivariate analysis, the presence of the cagA gene significantly increased the risk for developing gastric cancer and duodenal ulcer, with the presence of the homB gene acting as a factor that could distinguish gastric cancer from duodenal ulcer (adjusted odds ratio, 3.033; 95% confidence interval, ~1.37 to ~6.73). cagA status was correlated with homB status (r = 0.323; P < 0.01). A histological analysis showed that cagA status was associated with inflammation and atrophy both in the antrum and in the corpus, while homB status was associated with inflammation and atrophy in the corpus. homB gene status might be susceptible to gastric-cancer development such that the homB gene is used as a factor for discriminating the risk of gastric cancer from that of duodenal ulcer.

* Corresponding author. Mailing address: Department of Medicine, Michael E. DeBakey Veterans Affairs Medical Center (111D), Rm 3A-320, 2002 Holcombe Blvd., Houston, TX 77030. Phone: (713) 794-7597. Fax: (713) 795-4471. E-mail: yyamaoka{at}bcm.tmc.edu

{triangledown} Published ahead of print on 26 August 2009.

Journal of Clinical Microbiology, October 2009, p. 3241-3245, Vol. 47, No. 10
0095-1137/09/$08.00+0     doi:10.1128/JCM.00293-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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