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Journal of Clinical Microbiology, October 2009, p. 3323-3325, Vol. 47, No. 10
0095-1137/09/$08.00+0     doi:10.1128/JCM.01155-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Susceptibility of Clinical Isolates of Aspergillus spp. to Anidulafungin, Caspofungin, and Micafungin: a Head-to-Head Comparison Using the CLSI M38-A2 Broth Microdilution Method{triangledown}

M. A. Pfaller,1* L. Boyken,1 R. J. Hollis,1 J. Kroeger,1 S. A. Messer,1 S. Tendolkar,1 and D. J. Diekema1,2

Departments of Pathology,1 Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 522422

Received 12 June 2009/ Returned for modification 12 August 2009/ Accepted 18 August 2009

We determined the in vitro activities of anidulafungin, caspofungin, and micafungin against 526 isolates of Aspergillus spp. (64 A. flavus, 391 A. fumigatus, 46 A. niger, and 25 A. terreus isolates) collected from over 60 centers worldwide from 2001 through 2007. Susceptibility testing was performed according to the CLSI M38-A2 method. All three echinocandins—anidulafungin (50% minimum effective concentration [MEC50], 0.007 µg/ml; MEC90, 0.015 µg/ml), caspofungin (MEC50, 0.015 µg/ml; MEC90, 0.03 µg/ml), and micafungin (MEC50, 0.007 µg/ml; MEC90, 0.015 µg/ml)—were very active against Aspergillus spp. More than 99% of all isolates were inhibited by ≤0.06 µg/ml of all three agents.

* Corresponding author. Mailing address: Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242. Phone: (319) 356-8615. Fax: (319) 356-4916. E-mail: michael-pfaller{at}uiowa.edu

{triangledown} Published ahead of print on 26 August 2009.

Journal of Clinical Microbiology, October 2009, p. 3323-3325, Vol. 47, No. 10
0095-1137/09/$08.00+0     doi:10.1128/JCM.01155-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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