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Journal of Clinical Microbiology, October 2009, p. 3340-3343, Vol. 47, No. 10
0095-1137/09/$08.00+0     doi:10.1128/JCM.01061-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Population Structure Dynamics of Mycobacterium tuberculosis Beijing Strains during Past Decades in Japan {triangledown} ,{dagger}

Tomotada Iwamoto,1* Riyo Fujiyama,2 Shiomi Yoshida,3 Takayuki Wada,4 Chika Shirai,2 and Yasuto Kawakami2

Department of Microbiology, Kobe Institute of Health, Kobe, Japan,1 Public Health Center of Kobe City, Kobe, Japan,2 Clinical Research Center, National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Japan,3 Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, Osaka, Japan4

Received 1 June 2009/ Returned for modification 6 August 2009/ Accepted 14 August 2009

We used 909 strains to compare the population structures of the Mycobacterium tuberculosis Beijing family between different birth-year cohorts in Japan. The results revealed that the spread of a modern sublineage that has high transmissibility is currently increasing, while the spread of an ancient sublineage, STK, has significantly decreased in younger generations.

* Corresponding author. Mailing address: Department of Microbiology, Kobe Institute of Health, 4-6 Minatojima-Nakamachi, Chuo-ku, Kobe 650-0046, Japan. Phone: 81-78-302-6251. Fax: 81-78-302-0894. E-mail: kx2t-iwmt{at}asahi-net.or.jp

{triangledown} Published ahead of print on 6 August 2009.

{dagger} Supplemental material for this article may be found at http://jcm.asm.org/.

Journal of Clinical Microbiology, October 2009, p. 3340-3343, Vol. 47, No. 10
0095-1137/09/$08.00+0     doi:10.1128/JCM.01061-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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