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Journal of Clinical Microbiology, November 2009, p. 3760-3762, Vol. 47, No. 11
0095-1137/09/$08.00+0     doi:10.1128/JCM.00649-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antigenemia in Patients with Mediterranean Visceral Leishmaniasis{triangledown}

Bernard Ferrua,1,2* Nicolas Rol,1 Grégory Michel,1,2 and Pierre Marty1,2,3

Université de Nice Sophia Antipolis, Faculté de Médecine, Nice F-06107 Cedex 2, France,1 INSERM, U895, Centre Méditerranéen de Médecine Moléculaire (C3M), Equipe 6, Toxines Microbiennes dans la Relation Hôte-Pathogène, Nice F-06204 Cedex 3, France,2 Centre Hospitalier Universitaire de Nice, Laboratoire de Parasitologie-Mycologie, Nice F-06202 Cedex 3, France3

Received 31 March 2009/ Returned for modification 13 May 2009/ Accepted 3 September 2009

Antigenemia in patients with Mediterranean visceral leishmaniasis (MVL) due to Leishmania infantum was retrospectively assessed by sandwich enzyme-linked immunosorbent assay (ELISA). Circulating Leishmania antigens, partially in free form, were in evidence in 53% of serum samples from immunocompetent individuals with MVL. Following successful therapy, antigenemia decline as measured by ELISA was more pronounced than antibody decrease.

* Corresponding author. Mailing address: Bâtiment Universitaire Archimed, INSERM U895, C3M, Equipe 6, 151 Route St Antoine de Ginestière, BP 2 3194, 06204 Nice Cedex 3, France. Phone: 04 89 06 42 45. Fax: 33 4 89 06 42 21. E-mail: ferrua{at}unice.fr

{triangledown} Published ahead of print on 16 September 2009.

Journal of Clinical Microbiology, November 2009, p. 3760-3762, Vol. 47, No. 11
0095-1137/09/$08.00+0     doi:10.1128/JCM.00649-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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