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Journal of Clinical Microbiology, November 2009, p. 3763-3764, Vol. 47, No. 11
0095-1137/09/$08.00+0     doi:10.1128/JCM.00206-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Clinical and Resistance Consequences of Misquantification of Plasma and Cerebrospinal Fluid Human Immunodeficiency Virus Type 1 (HIV-1) RNA in Samples from an HIV-1 Subtype G-Infected Patient{triangledown}

Constance Delaugerre,1* Blandine Denis,2 Gilles Peytavin,3 Pierre Palmer,1 Thomas Mourez,1 Jerôme Le Goff,1 Jean-Michel Molina,2 and François Simon1

Department of Virology, Saint-Louis Hospital-APHP, Paris, France,1 Department of Infectious Diseases, Saint-Louis Hospital-APHP, Paris, France,2 Department of Pharmacology, Bichat-Claude Bernard Hospital-APHP, Paris, France3

Received 31 January 2009/ Returned for modification 13 May 2009/ Accepted 31 July 2009

Human immunodeficiency virus (HIV) load is the main marker used to monitor antiviral treatment efficacy and resistance. We report a case of underquantification of HIV type 1 (HIV-1) RNA in plasma and cerebrospinal fluid from an HIV-1 subtype G-infected woman, leading to delayed diagnosis of HIV encephalitis and to the emergence of drug resistance.

* Corresponding author. Mailing address: Department of Virology, Saint-Louis Hospital, 1 avenue Claude Vellefaux, 75010 Paris, France. Phone: 33 1 42499490. Fax: 33 1 42499200. E-mail: constance.delaugerre{at}sls.aphp.fr

{triangledown} Published ahead of print on 16 September 2009.

Journal of Clinical Microbiology, November 2009, p. 3763-3764, Vol. 47, No. 11
0095-1137/09/$08.00+0     doi:10.1128/JCM.00206-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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