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Journal of Clinical Microbiology, November 2009, p. 3773-3776, Vol. 47, No. 11
0095-1137/09/$08.00+0     doi:10.1128/JCM.01712-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Airway Obstruction Is Increased in Pneumocystis-Colonized Human Immunodeficiency Virus-Infected Outpatients{triangledown}

Alison Morris,1,2* Travis Alexander,1 Saba Radhi,1 Lorrie Lucht,2 Frank C. Sciurba,2 Jay K. Kolls,3 Ruma Srivastava,3 Chad Steele,4 and Karen A. Norris2

Department of Medicine, Division of Pulmonary and Critical Care Medicine and the Will Rogers Institute Pulmonary Research Center, University of Southern California, Los Angeles, California,1 Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania,2 Department of Pediatrics, Division of Pediatric Pulmonary Medicine, Allergy, and Immunology,,3 Department of Medicine, University of Alabama, Birmingham, Alabama4

Received 1 September 2009/ Accepted 3 September 2009

We investigated the relationship of Pneumocystis colonization, matrix metalloprotease levels in sputum, and airway obstruction in a cohort of human immunodeficiency virus (HIV)-infected outpatients. Pneumocystis-colonized subjects had worse obstruction of airways and higher levels of matrix metalloprotease-12 in sputa, suggesting that Pneumocystis colonization may be important in HIV-associated chronic obstructive pulmonary disease.

* Corresponding author. Mailing address: University of Pittsburgh Medical Center, 628 NW MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213. Phone: (412) 647-4686. Fax: (412) 692-2260. E-mail: morrisa{at}upmc.edu

{triangledown} Published ahead of print on 16 September 2009.

Journal of Clinical Microbiology, November 2009, p. 3773-3776, Vol. 47, No. 11
0095-1137/09/$08.00+0     doi:10.1128/JCM.01712-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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