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Journal of Clinical Microbiology, November 2009, p. 3783-3784, Vol. 47, No. 11
0095-1137/09/$08.00+0     doi:10.1128/JCM.00927-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

CASE REPORT

False-Positive PCR Detection of Tropheryma whipplei in Cerebrospinal Fluid and Biopsy Samples from a Child with Chronic Lymphocytic Meningitis {triangledown}

Daniel Goyo,1 Ana Camacho,2 Carmen Gómez,3 Rogelio Simón de las Heras,2 Joaquín R. Otero,3 and Fernando Chaves3*

Servicio Neurología,1 Sección de Neurología Infantil,2 Servicio de Microbiología, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain3

Received 12 May 2009/ Returned for modification 31 July 2009/ Accepted 1 September 2009

We report the case of a teenager with chronic lymphocytic meningitis for whom Tropheryma whipplei 16S rRNA PCR results were positive in two cerebrospinal fluid samples and one duodenal biopsy specimen. PCR targeting another specific sequence of Tropheryma whipplei and sequencing of the initially amplified 16S rRNA fragment did not confirm the results.

* Corresponding author. Mailing address: Servicio de Microbiología, Hospital Universitario 12 de Octubre, Avenida de Córdoba sn, Madrid 28041, Spain. Phone: (34) 91-3908239. Fax: (34) 91-5652765. E-mail: fchaves.hdoc{at}salud.madrid.org

{triangledown} Published ahead of print on 9 September 2009.

Journal of Clinical Microbiology, November 2009, p. 3783-3784, Vol. 47, No. 11
0095-1137/09/$08.00+0     doi:10.1128/JCM.00927-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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