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Journal of Clinical Microbiology, February 2009, p. 485-488, Vol. 47, No. 2
0095-1137/09/$08.00+0     doi:10.1128/JCM.01678-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Use of the Novel INNO-LiPA Line Probe Assay for Detection of Hepatitis B Virus Variants That Confer Resistance to Entecavir Therapy{triangledown}

Rosendo Jardi,1,3* Francisco Rodriguez-Frias,1,3 David Tabernero,3 Maria Homs,3 Melanie Schaper,1 Rafael Esteban,2,3 and Maria Buti2,3

Departments of Biochemistry,1 Hepatology, Hospital Universitario Vall d'Hebron, Barcelona, Spain,2 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain3

Received 29 August 2008/ Returned for modification 8 October 2008/ Accepted 22 November 2008

A line probe assay (INNO-LiPA DR, version 3) for the detection of hepatitis B virus mutations that confer resistance to entecavir therapy was evaluated. The INNO-LiPA DR assay is a highly sensitive assay that is easily applicable for the detection and monitoring of entecavir resistance-conferring mutations and is more sensitive than sequencing for the detection of mixed sequences.

* Corresponding author. Mailing address: Servicio de Bioquímica, Hospital General Vall d'Hebrón, Paseo Valle Hebrón s/n, Barcelona 08035, Spain. Phone: 34 (93) 2746100. Fax: 34 (93) 2746831. E-mail: rjardi{at}vhebron.net

{triangledown} Published ahead of print on 3 December 2008.

Journal of Clinical Microbiology, February 2009, p. 485-488, Vol. 47, No. 2
0095-1137/09/$08.00+0     doi:10.1128/JCM.01678-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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