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Journal of Clinical Microbiology, February 2009, p. 492-495, Vol. 47, No. 2
0095-1137/09/$08.00+0     doi:10.1128/JCM.01833-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Fourteen Years of Severe Arthralgia in a Man without Gastrointestinal Symptoms: Atypical Whipple's Disease {triangledown}

Fabiola Mancini,1 Serena Sbaragli,2 Gilberto Colivicchi,2 Antonio Cassone,1 and Alessandra Ciervo1*

Department of Infectious, Parasitic, and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy,1 Department of Internal Medicine, Istituto Fiorentino di Cura e Assistenza, Florence, Italy2

Received 22 September 2008/ Returned for modification 30 October 2008/ Accepted 9 December 2008

We report here the case of Whipple's disease in a 60-year-old man with severe arthralgia and systemic disorders but without gastrointestinal manifestations. The patient had different clinical diagnoses over a period of 14 years. We identified Tropheryma whipplei by real-time PCR. Molecular typing was also performed by sequencing the 16S-23S rRNA intergenic spacer region and domain III of the 23S rRNA gene.

* Corresponding author. Mailing address: Department of Infectious, Parasitic, and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299-00161, Rome, Italy. Phone: 0039-06-49903127. Fax: 0039-06-49387183. E-mail: alessandra.ciervo{at}iss.it

{triangledown} Published ahead of print on 17 December 2008.

Journal of Clinical Microbiology, February 2009, p. 492-495, Vol. 47, No. 2
0095-1137/09/$08.00+0     doi:10.1128/JCM.01833-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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