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Journal of Clinical Microbiology, March 2009, p. 771-773, Vol. 47, No. 3
0095-1137/09/$08.00+0     doi:10.1128/JCM.02331-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Detection of Viruses in Human Adenoid Tissues by Use of Multiplex PCR{triangledown}

Masatoki Sato,1,5,6 Haijing Li,2 Mine R. Ikizler,1 Jay A. Werkhaven,3 John V. Williams,1 James D. Chappell,1,4 Yi-Wei Tang,2,4 and Peter F. Wright1,4,6*

Departments of Pediatrics,1 Medicine,2 Otolaryngology,3 Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232,4 Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan,5 Department of Pediatrics, Dartmouth Medical School, Hanover, New Hampshire 037556

Received 3 December 2008/ Returned for modification 15 December 2008/ Accepted 22 December 2008

By PCR, we detected a high frequency of viruses in adenoids obtained from children without acute respiratory symptoms. Our results suggest that persistent/latent viral infection in the respiratory tract confounds interpretation of the association of pathogen detection by PCR with acute respiratory infection in these sources.

* Corresponding author. Mailing address: Dartmouth Medical School, 1 Medical Center Drive, Lebanon, New Hampshire 03756. Phone: (603) 653-6190. Fax: (603) 650-6199. E-mail: Peter.F.Wright{at}Dartmouth.edu

{triangledown} Published ahead of print on 30 December 2008.

Journal of Clinical Microbiology, March 2009, p. 771-773, Vol. 47, No. 3
0095-1137/09/$08.00+0     doi:10.1128/JCM.02331-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Miller, M. B., Tang, Y.-W. (2009). Basic Concepts of Microarrays and Potential Applications in Clinical Microbiology. Clin. Microbiol. Rev. 22: 611-633 [Abstract] [Full Text]  
  • Herberhold, S., Eis-Hubinger, A.-M., Panning, M. (2009). Frequent Detection of Respiratory Viruses by Real-Time PCR in Adenoid Samples from Asymptomatic Children. J. Clin. Microbiol. 47: 2682-2683 [Full Text]  


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