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Journal of Clinical Microbiology, March 2009, p. 777-780, Vol. 47, No. 3
0095-1137/09/$08.00+0     doi:10.1128/JCM.01660-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Occurrence of spvA Virulence Gene and Clinical Significance for Multidrug-Resistant Salmonella Strains {triangledown}

Wondwossen A. Gebreyes,1* Siddhartha Thakur,2 Paul Dorr,3 Daniel A. Tadesse,1 Karen Post,4 and Leslie Wolf5

The Ohio State University, College of Veterinary Medicine, Department of Veterinary Preventive Medicine, Columbus, Ohio,1 North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina,2 Research and Development, Merial Limited, Duluth, Georgia,3 North Carolina Department of Agriculture and Consumer Services, Rollins Animal Disease Diagnostic Laboratory, Raleigh, North Carolina,4 North Carolina State Laboratory of Public Health (NCSLPH), Raleigh, North Carolina5

Received 26 August 2008/ Returned for modification 19 November 2008/ Accepted 22 December 2008

Nontyphoidal Salmonella strains are important reservoirs of antimicrobial resistance. An important issue that has not been investigated is whether the multiresistant Salmonella strains are more virulent than their susceptible counterparts. Salmonella isolates collected from clinical human (n = 888) and porcine (n = 2,120) cases at the same time period and geographic location were investigated. Antimicrobial susceptibility, PCR analysis for the spvA virulence gene, and pulsed-field gel electrophoresis (PFGE) genotyping were done. Carriage of spvA was associated with multidrug-resistant (MDR) type ACSSuT strains (odds ratio, 7.1; P < 0.05), a type often implicated in bacteremic human cases. PFGE revealed that clinical isolates from pigs were more clonally related to those of human origin than the nonclinical porcine isolates. The findings suggest that MDR strains that also carry specific virulence factors are more likely to be of clinical significance.

* Corresponding author. Mailing address: The Ohio State University, College of Veterinary Medicine, Department of Veterinary Preventive Medicine, Columbus, OH. Phone: (614) 292-9559. Fax: (614) 292-4142. E-mail: gebreyes.1{at}osu.edu

{triangledown} Published ahead of print on 30 December 2008.

Journal of Clinical Microbiology, March 2009, p. 777-780, Vol. 47, No. 3
0095-1137/09/$08.00+0     doi:10.1128/JCM.01660-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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