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Journal of Clinical Microbiology, March 2009, p. 823-826, Vol. 47, No. 3
0095-1137/09/$08.00+0     doi:10.1128/JCM.01884-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Rapid Detection of Staphylococcus aureus and Methicillin-Resistant S. aureus (MRSA) in Wound Specimens and Blood Cultures: Multicenter Preclinical Evaluation of the Cepheid Xpert MRSA/SA Skin and Soft Tissue and Blood Culture Assays{triangledown}

D. M. Wolk,1* M. J. Struelens,2 P. Pancholi,3 T. Davis,4 P. Della-Latta,5 D. Fuller,4 E. Picton,1 R. Dickenson,6 O. Denis,2 D. Johnson,1 and K. Chapin6

University of Arizona/BIO5 Institute, Tucson, Arizona,1 ULB-Hopital Erasme, Brussels, Belgium,2 The Ohio State University Medical Center, Columbus, Ohio,3 Wishard Memorial Hospital, Indiana University, Indianapolis, Indiana,4 Columbia University College of Physicians and Surgeons, New York, New York,5 Lifespan Academic Medical Centers and Brown Medical School, Providence, Rhode Island6

Received 30 September 2008/ Returned for modification 19 November 2008/ Accepted 5 January 2009

A multicenter preclinical evaluation was conducted to evaluate the performance of two Cepheid Xpert assays for detection of methicillin-resistant Staphylococcus aureus (MRSA) and S. aureus. Sensitivity was 97.1% and 98.3% for MRSA in wound and blood culture specimens, respectively. Sensitivity was 100% for S. aureus from both specimen types.

* Corresponding author. Mailing address: Clinical and Molecular Microbiology, University of Arizona, Pathology, BIO5 Institute, 1501 N. Campbell Ave., P.O. Box 245059, Tucson, AZ 85724-5059. Phone: (520) 626-3676. Fax: (520) 694-7329. E-mail: dwolk{at}email.arizona.edu

{triangledown} Published ahead of print on 14 January 2009.

Journal of Clinical Microbiology, March 2009, p. 823-826, Vol. 47, No. 3
0095-1137/09/$08.00+0     doi:10.1128/JCM.01884-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Snyder, J. W., Munier, G. K., Heckman, S. A., Camp, P., Overman, T. L. (2009). Failure of the BD GeneOhm StaphSR Assay for Direct Detection of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Isolates in Positive Blood Cultures Collected in the United States. J. Clin. Microbiol. 47: 3747-3748 [Abstract] [Full Text]  


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