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Journal of Clinical Microbiology, April 2009, p. 1221-1224, Vol. 47, No. 4
0095-1137/09/$08.00+0     doi:10.1128/JCM.01959-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Molecular Epidemiological Investigation of a Nosocomial Outbreak of Human Metapneumovirus Infection in a Pediatric Hemato-Oncology Patient Population{triangledown}

Sollip Kim,1 Heungsup Sung,1 Ho Joon Im,2 Soo-Jong Hong,2 and Mi-Na Kim1*

Department of Laboratory Medicine,1 Pediatrics, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea2

Received 10 October 2008/ Returned for modification 3 December 2008/ Accepted 4 February 2009

We report the first nosocomial outbreak of human metapneumovirus (hMPV) infection in a pediatric patient population. Among 15 pediatric hMPV infections from March to May 2007, there was a nosocomial outbreak involving two patients sharing a room in a hemato-oncology ward with a patient with a community-acquired case of hMPV infection. The estimated incubation period was 7 to 9 days for a symptomatic nosocomial case. Sequencing of fusion genes of 15 isolates revealed two clusters belonging to subgroup A2 and one cluster belonging to subgroup B2. Three isolates from the outbreak had sequences identical to those of samples in the A2 cluster. There was also a separate nosocomial case represented by the B2 cluster.

* Corresponding author. Mailing address: Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Asanbyeongwon-gil 86, Songpa-gu, Seoul 138-736, Republic of Korea. Phone: 82.2.30104511. Fax: 82.2.4780884. E-mail: mnkim{at}amc.seoul.kr

{triangledown} Published ahead of print on 11 February 2009.

Journal of Clinical Microbiology, April 2009, p. 1221-1224, Vol. 47, No. 4
0095-1137/09/$08.00+0     doi:10.1128/JCM.01959-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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