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Journal of Clinical Microbiology, April 2009, p. 1244-1248, Vol. 47, No. 4
0095-1137/09/$08.00+0     doi:10.1128/JCM.02030-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Mucor circinelloides as a Cause of Invasive Maxillofacial Zygomycosis: an Emerging Dimorphic Pathogen with Reduced Susceptibility to Posaconazole{triangledown}

Zia U. Khan,1* Suhail Ahmad,1 Arnost Brazda,2 and Rachel Chandy1

Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait,1 Department of Maxillofacial Surgery, Farwanya Hospital, Ministry of Health, Farwanya, Kuwait2

Received 20 October 2008/ Returned for modification 8 December 2008/ Accepted 7 January 2009

A case of maxillofacial zygomycosis caused by Mucor circinelloides, identified by phenotypic and molecular methods and treated successfully with liposomal amphotericin B (AmBisome) and surgical debridement, is described. The isolate was resistant to posaconazole. This report underscores the importance of prior susceptibility testing of zygomycetes to guide therapy with the most effective antifungal agent for an improved prognosis.


* Corresponding author. Mailing address: Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat, Kuwait 13110. Phone: 00965-25312300-6504. Fax: 00965-25318454/25332719. E-mail: zkhan{at}hsc.edu.kw

{triangledown} Published ahead of print on 26 January 2009.


Journal of Clinical Microbiology, April 2009, p. 1244-1248, Vol. 47, No. 4
0095-1137/09/$08.00+0     doi:10.1128/JCM.02030-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.