This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by N'Guyen, Y.
Right arrow Articles by Strady, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by N'Guyen, Y.
Right arrow Articles by Strady, C.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, April 2009, p. 1252-1254, Vol. 47, No. 4
0095-1137/09/$08.00+0     doi:10.1128/JCM.02052-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Fatal Epstein-Barr Virus Primo Infection in a 25-Year-Old Man Treated with Azathioprine for Crohn's Disease {triangledown}

Y. N'Guyen,1 L. Andreoletti,2 M. Patey,3 C. Lecoq-Lafon,4 P. Cornillet,5 A. Léon,6 R. Jaussaud,1 C. Fieschi,7 and C. Strady1*

Service de Médicine Interne et des Maladies Infectieuses, Hôpital Robert Debré-CHU Reims, Reims, France,1 Laboratoire de Virologie Médicale et Moléculaire, EA4303/IFR53, CHU Reims, Hôpital Robert Debré, Reims, France,2 Laboratoire d'Anatomo-pathologie, Hôpital Robert Debré-CHU Reims, Avenue du Général Koenig, Reims, France,3 Laboratoire d'Hématologie, Hôpital Robert Debré-CHU Reims, Avenue du Général Koenig, Reims, France,4 Laboratoire de Cytogénétique, Hôpital Maison-Blanche-CHU Reims, Reims, France,5 Département d'Anesthésie-Réanimation, Hôpital Robert Debré-CHU Reims, Reims, France,6 Unité d'Immunopathologie, Département d'Immunologie Clinique, EA3963 Centre Hayem, Hôpital Saint Louis, 75010 Paris, France7

Received 22 October 2008/ Returned for modification 16 December 2008/ Accepted 28 January 2009

We report a case of Epstein-Barr virus (EBV) primo infection with the development of successive infectious mononucleosis, hemophagocytic lymphohistiocytosis, and B-cell lymphoproliferative disorder in a patient treated with azathioprine for Crohn's disease. This case report suggests that specific EBV-related clinical and virological management should be considered when treating a patient with inflammatory bowel disease with azathioprine.

* Corresponding author. Mailing address: Service de Médicine Interne et des Maladies Infectieuses, Hôpital Robert Debré, CHU Reims, Avenue du Général Koenig, 51093 Reims Cedex, France. Phone: 00333-26-78-78-94. Fax: 00333-26-78-40-90. E-mail: cstrady{at}chu-reims.fr

{triangledown} Published ahead of print on 4 February 2009.

Journal of Clinical Microbiology, April 2009, p. 1252-1254, Vol. 47, No. 4
0095-1137/09/$08.00+0     doi:10.1128/JCM.02052-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»