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Journal of Clinical Microbiology, May 2009, p. 1549-1552, Vol. 47, No. 5
0095-1137/09/$08.00+0     doi:10.1128/JCM.00047-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Clinical and Molecular Epidemiology of Human Parainfluenza Virus 4 Infections in Hong Kong: Subtype 4B as Common as Subtype 4A{triangledown}

Susanna K. P. Lau,1,2,3 Kenneth S. M. Li,3 Kam-yu Chau,3 Lok-yee So,4 Rodney A. Lee,5 Yu-lung Lau,6 Kwok-hung Chan,3 Wilina W. L. Lim,7 Patrick C. Y. Woo,1,2,3* and Kwok-yung Yuen1,2,3*

State Key Laboratory of Emerging Infectious Diseases,1 Research Centre of Infection and Immunology,2 Department of Microbiology, The University of Hong Kong, Hong Kong,3 Department of Paediatrics and Adolescent Medicine,4 Department of Pathology, Pamela Youde Nethersole Eastern Hospital, Hong Kong,5 Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong,6 Public Health Laboratory Centre, Centre for Health Protection, Hong Kong7

Received 8 January 2009/ Returned for modification 13 February 2009/ Accepted 25 February 2009

In this 1-year study, 35 (1.2%) of 2,912 nasopharyngeal aspirates were positive for human parainfluenza virus 4 (HPIV4) by reverse transcription-PCR. Patients with HPIV4 infection were mainly young children and immunocompromised adults. In contrast to the reported predominance of HPIV4A infection, molecular subtyping revealed that 15 (44%) cases were caused by HPIV4B.

* Corresponding author. Mailing address for P. C. Y. Woo: Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong. Phone: (852) 28554892. Fax: (852) 28551241. E-mail: pcywoo{at}hkucc.hku.hk. Mailing address for K. Y. Yuen: Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong. Phone: (852) 28554892. Fax: (852) 28551241. E-mail: kyyuen{at}hkucc.hku.hk

{triangledown} Published ahead of print on 4 March 2009.

Journal of Clinical Microbiology, May 2009, p. 1549-1552, Vol. 47, No. 5
0095-1137/09/$08.00+0     doi:10.1128/JCM.00047-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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