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Journal of Clinical Microbiology, May 2009, p. 1556-1558, Vol. 47, No. 5
0095-1137/09/$08.00+0     doi:10.1128/JCM.01657-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Variations in Ceftazidime and Amoxicillin-Clavulanate Susceptibilities within a Clonal Infection of Burkholderia pseudomallei{triangledown}

I-Ching Sam,* Kah Heng See, and Savithri D. Puthucheary

Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia

Received 26 August 2008/ Returned for modification 11 February 2009/ Accepted 5 March 2009

A patient with a clonal infection of Burkholderia pseudomallei had subpopulations with ceftazidime and amoxicillin-clavulanate susceptibilities that differed among the clinical specimens. Resistance was associated with a novel Cys69Tyr substitution in the Ambler class A β-lactamase. Susceptibility testing of multiple colony variants from different sites should be performed for patients with culture-confirmed melioidosis.

* Corresponding author. Mailing address: Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia. Phone: 60 3 7949 2184. Fax: 60 3 7967 5753. E-mail: wicsam{at}doctors.net.uk

{triangledown} Published ahead of print on 18 March 2009.

Journal of Clinical Microbiology, May 2009, p. 1556-1558, Vol. 47, No. 5
0095-1137/09/$08.00+0     doi:10.1128/JCM.01657-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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