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Journal of Clinical Microbiology, May 2009, p. 1585-1587, Vol. 47, No. 5
0095-1137/09/$08.00+0     doi:10.1128/JCM.02385-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

"Mycobacterium tilburgii," a Newly Described, Uncultivated Opportunistic Pathogen{triangledown}

Tara N. Palmore,1* Yvonne R. Shea,2 Patricia S. Conville,2 Frank G. Witebsky,2 Victoria L. Anderson,1 Irene P. Rupp Hodge,3 and Steven M. Holland1

Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland,1 Microbiology Service, Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland,2 Rochester Infectious Disease, Frisbie Memorial Hospital, Rochester, New Hampshire3

Received 12 December 2008/ Returned for modification 3 February 2009/ Accepted 20 February 2009

Molecular methods are increasingly used to identify pathogens that are difficult to cultivate. We report a case of disseminated infection with "Mycobacterium tilburgii," a proposed species that has never been cultivated. The case illustrates the diagnostic utility of sequence analysis of the 16S rRNA gene directly from clinical specimens.


* Corresponding author. Mailing address: 10 Center Dr., Room 12C103A, Bethesda, MD 20892-1888. Phone: (301) 594-6818. Fax: (301) 496-7383. E-mail: tpalmore{at}mail.nih.gov

{triangledown} Published ahead of print on 4 March 2009.


Journal of Clinical Microbiology, May 2009, p. 1585-1587, Vol. 47, No. 5
0095-1137/09/$08.00+0     doi:10.1128/JCM.02385-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.