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Journal of Clinical Microbiology, June 2009, p. 1899-1901, Vol. 47, No. 6
0095-1137/09/$08.00+0     doi:10.1128/JCM.02438-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

No Correlation between Giant Cell Arteritis and Chlamydia pneumoniae Infection: Investigation of 189 Patients by Standard and Improved PCR Methods{triangledown}

Florence Njau,1,{dagger}* Thomas Ness,2,{dagger} Ulrike Wittkop,1 Thorsten Pancratz,1 Meike Eickhoff,3 Alan P. Hudson,4 Hermann Haller,1 and Annette D. Wagner1

Hannover Medical School, Department of Internal Medicine, Division of Nephrology, Hannover D-30625, Germany,1 University Hospital Freiburg, Department of Ophthalmology, Freiburg, Germany,2 Roche Diagnostics Ltd., CH-6343 Rotkreuz, Switzerland,3 Wayne State University, School of Medicine, Department of Immunology and Microbiology, Detroit, Michigan, 482014

Received 19 December 2008/ Returned for modification 26 January 2009/ Accepted 13 April 2009

A total of 189 temporal artery biopsy samples from giant cell arteritis (GCA) patients were investigated using sensitive PCR targeting Chlamydia pneumoniae. Chlamydial DNA was detected in 17 samples, 11 of which were positive for chlamydial antigens. Our data did not reveal strong evidence that C. pneumoniae plays an important role in the pathogenesis of GCA.

* Corresponding author. Mailing address: Department of Internal Medicine, Division of Nephrology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany. Phone: 49-511-532-2719. Fax: 49-511-532-2713. E-mail: fnjau{at}yahoo.com

{triangledown} Published ahead of print on 22 April 2009.

{dagger} F.N. and T.N. contributed equally to the manuscript.

Journal of Clinical Microbiology, June 2009, p. 1899-1901, Vol. 47, No. 6
0095-1137/09/$08.00+0     doi:10.1128/JCM.02438-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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