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Journal of Clinical Microbiology, June 2009, p. 1911-1914, Vol. 47, No. 6
0095-1137/09/$08.00+0     doi:10.1128/JCM.00535-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

First Insight into Mycobacterium tuberculosis Epidemiology and Genetic Diversity in Trinidad and Tobago{triangledown}

Shirematee Baboolal,1,2 Julie Millet,3 Patrick Eberechi Akpaka,1 Dottin Ramoutar,4 and Nalin Rastogi3*

Department of Para-Clinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago,1 Caribbean Epidemiology Centre, Jamaica Boulevard, Port of Spain, Trinidad and Tobago,2 Unité de la Tuberculose et des Mycobactéries, Institut Pasteur de Guadeloupe, Abymes, Guadeloupe,3 Caura Chest Hospital, Caura, Trinidad and Tobago4

Received 16 March 2009/ Returned for modification 13 April 2009/ Accepted 17 April 2009

This report is based on a 1-year recruitment of all of the culture-positive Mycobacterium tuberculosis cases in Trinidad and Tobago (n = 132). The study population was characterized by a high male-to-female sex ratio of 4 and a human immunodeficiency virus-tuberculosis (TB) coinfection rate of 30%. It mainly occurred among African descendants, who represent 37.5% of the total population but 69.7% of all TB cases (P < 0.001). Spoligotyping resulted in 25 different patterns and 12 clusters (2 to 74 strains per cluster), with the predominance of a highly conserved spoligotype international type clone, SIT566.

* Corresponding author. Mailing address: Unité de la Tuberculose et des Mycobactéries, Institut Pasteur de Guadeloupe, 97183-Abymes Cedex, Guadeloupe, France. Phone: 590-590-897661. Fax: 590-590-896941. E-mail: nrastogi{at}pasteur-guadeloupe.fr

{triangledown} Published ahead of print on 29 April 2009.

Journal of Clinical Microbiology, June 2009, p. 1911-1914, Vol. 47, No. 6
0095-1137/09/$08.00+0     doi:10.1128/JCM.00535-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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