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Journal of Clinical Microbiology, July 2009, p. 2292-2294, Vol. 47, No. 7
0095-1137/09/$08.00+0     doi:10.1128/JCM.02439-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Genotypic Prediction of Human Immunodeficiency Virus Type 1 CRF02-AG Tropism{triangledown}

Stéphanie Raymond,1,2,3 Pierre Delobel,1,4 Maud Mavigner,1 Michelle Cazabat,1,3 Corinne Souyris,1,3 Stéphanie Encinas,1,3 Karine Sandres-Sauné,1,2,3 Christophe Pasquier,1,2,3 Bruno Marchou,2,4 Patrice Massip,2,4 and Jacques Izopet1,2,3*

INSERM, U563, Toulouse F-31300, France,1 Université Toulouse III Paul-Sabatier, Faculté de Médecine Toulouse-Purpan, Toulouse F-31300, France,2 CHU de Toulouse, Hôpital Purpan, Laboratoire de Virologie, Toulouse F-31300, France,3 CHU de Toulouse, Hôpital Purpan, Service des Maladies Infectieuses et Tropicales, Toulouse F-31300, France4

Received 19 December 2008/ Returned for modification 5 March 2009/ Accepted 6 May 2009

We assessed the performance of genotypic algorithms for predicting the tropism of human immunodeficiency virus type 1 coreceptor usage in 52 patients infected with the CRF02-AG subtype. The combined criteria of the 11/25 and net charge rules accurately detected CXCR4-using CRF02-AG viruses, whereas the Geno2pheno tool lacked sensitivity and the position-specific scoring matrix (PSSM) tool WebPSSM lacked specificity.

* Corresponding author. Mailing address: CHU de Toulouse, Hôpital Purpan, Laboratoire de Virologie, Toulouse F-31300, France. Phone: 33 5 67 69 04 24. Fax: 33 5 67 69 04 25. E-mail: izopet.j{at}chu-toulouse.fr

{triangledown} Published ahead of print on 13 May 2009.

Journal of Clinical Microbiology, July 2009, p. 2292-2294, Vol. 47, No. 7
0095-1137/09/$08.00+0     doi:10.1128/JCM.02439-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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