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Journal of Clinical Microbiology, July 2009, p. 2325-2327, Vol. 47, No. 7
0095-1137/09/$08.00+0     doi:10.1128/JCM.02141-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Immediate Appearance of Plasmid-Mediated Resistance to Multiple Antibiotics upon Antibiotic Selection: an Argument for Systematic Resistance Epidemiology{triangledown}

Sebastiaan J. van Hal,1 Agnieszka Wiklendt,1 Björn Espedido,2 Andrew Ginn,2 and Jonathan R. Iredell1,2*

Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research,1 University of Sydney, Westmead Hospital, Sydney, New South Wales, Australia 21452

Received 8 November 2008/ Returned for modification 5 January 2009/ Accepted 16 April 2009

We describe a conjugative plasmid appearing in a bacteremic clone of Escherichia coli immediately upon exposure to the antibiotics for which it encoded resistance. Effective antibiotic choice was made possible by prior screening for this plasmid. Surveillance for transmissible resistance plasmids may be clinically important.

* Corresponding author. Mailing address: Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Sydney, New South Wales, Australia 2145. Phone: 61 2 9845 6255. Fax: 61 2 9891 5317. E-mail: jon.iredell{at}swahs.health.nsw.gov.au

{triangledown} Published ahead of print on 6 May 2009.

Journal of Clinical Microbiology, July 2009, p. 2325-2327, Vol. 47, No. 7
0095-1137/09/$08.00+0     doi:10.1128/JCM.02141-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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