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Journal of Clinical Microbiology, August 2009, p. 2601-2603, Vol. 47, No. 8
0095-1137/09/$08.00+0     doi:10.1128/JCM.02351-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Evaluation of GenoType Mycobacteria Direct Assay in Comparison with Gen-Probe Mycobacterium tuberculosis Amplified Direct Test and GenoType MTBDRplus for Direct Detection of Mycobacterium tuberculosis Complex in Clinical Samples{triangledown}

Ioannis K. Neonakis,1,{dagger}* Zoe Gitti,1,{dagger} Stavroula Baritaki,2 Efi Petinaki,3 Maria Baritaki,1 and Demetrios A. Spandidos1,2

Mycobacteriology Laboratory, Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, University Hospital of Heraklion, Heraklion, Greece,1 Department of Laboratory Medicine, School of Medicine, University of Crete, Heraklion, Greece,2 Department of Microbiology, School of Medicine, University of Thessaly, Larissa, Greece3

Received 8 December 2008/ Returned for modification 26 April 2009/ Accepted 14 June 2009

Three molecular assays were evaluated for the direct detection of Mycobacterium tuberculosis complex bacteria in 125 respiratory and 22 nonrespiratory samples. The overall sensitivities obtained were as follows: GenoType MTBDRplus, 97.9%; GenoType Mycobacteria Direct, 93.7%; Gen-Probe Mycobacterium tuberculosis Amplified Direct Test, 89.6%. The specificity of the assays used was 100%.

* Corresponding author. Mailing address: Mycobacteriology Laboratory, Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, University Hospital of Heraklion, 712 01 Heraklion, Crete, Greece. Phone: 30 2810 392599. Fax: 30 210 7252922. E-mail: ineonakis{at}gmail.com

{triangledown} Published ahead of print on 24 June 2009.

{dagger} These authors contributed equally to this study.

Journal of Clinical Microbiology, August 2009, p. 2601-2603, Vol. 47, No. 8
0095-1137/09/$08.00+0     doi:10.1128/JCM.02351-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Syre, H., Myneedu, V. P., Arora, V. K., Grewal, H. M. S. (2009). Direct Detection of Mycobacterial Species in Pulmonary Specimens by Two Rapid Amplification Tests, the Gen-Probe Amplified Mycobacterium tuberculosis Direct Test and the GenoType Mycobacteria Direct Test. J. Clin. Microbiol. 47: 3635-3639 [Abstract] [Full Text]  


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