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Journal of Clinical Microbiology, August 2009, p. 2604-2606, Vol. 47, No. 8
0095-1137/09/$08.00+0     doi:10.1128/JCM.00632-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Assessing Human Immunodeficiency Virus Type 1 Tropism: Comparison of Assays Using Replication-Competent Virus versus Plasma-Derived Pseudotyped Virions {triangledown}

Noriaki Hosoya,1 Zhaohui Su,2 Timothy Wilkin,3 Roy M. Gulick,3 Charles Flexner,4 Michael D. Hughes,2 Paul R. Skolnik,5 Françoise Giguel,1 Wayne L. Greaves,6 Eoin Coakley,7 and Daniel R. Kuritzkes1*

Section of Retroviral Therapeutics, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts,1 Harvard School of Public Health, Boston, Massachusetts,2 Weill Medical College, Cornell University, New York, New York,3 Johns Hopkins University, Baltimore, Maryland,4 Boston University Medical Center, Boston, Massachusetts,5 Schering-Plough Research Institute, Kenilworth, New Jersey,6 Monogram Biosciences, South San Francisco, California7

Received 29 March 2009/ Returned for modification 6 May 2009/ Accepted 26 May 2009

Detection of CXCR4-using human immunodeficiency virus by the Trofile assay was compared to that by assays using virus isolates or replication-competent recombinants. Concordance with the Trofile assay was good, but assays using replicating viruses did not increase substantially the ability to detect the presence of CXCR4-using virus.

* Corresponding author. Mailing address: Brigham and Women's Hospital, 65 Landsdowne Street, Room 449, Cambridge, MA 02139. Phone: (617) 768-8371. Fax: (617) 768-8738. E-mail: dkuritzkes{at}partners.org

{triangledown} Published ahead of print on 3 June 2009.

Journal of Clinical Microbiology, August 2009, p. 2604-2606, Vol. 47, No. 8
0095-1137/09/$08.00+0     doi:10.1128/JCM.00632-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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