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Journal of Clinical Microbiology, August 2009, p. 2611-2615, Vol. 47, No. 8
0095-1137/09/$08.00+0     doi:10.1128/JCM.00278-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Human Papillomavirus Genotype Specificity of Hybrid Capture 2 Low-Risk Probe Cocktail{triangledown}

Mario Poljak,1* Bostjan J. Kocjan,1 Anja Kovanda,1 Maja M. Lunar,1 Snjezana Zidovec Lepej,2 Ana Planinic,2 Katja Seme,1 and Adriana Vince2

Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Slovenia,1 University Hospital for Infectious Diseases, Zagreb, Croatia2

Received 8 February 2009/ Returned for modification 19 March 2009/ Accepted 26 May 2009

A genotyping study of 285 Hybrid Capture 2 low-risk probe cocktail-positive specimens showed cross-reactivity with several untargeted human papillomavirus genotypes. Cross-reactivity was often clinically beneficial due to the detection of untargeted low-risk genotypes. A total of 8.4% of positive results, usually weak, were due to cross-reactivity with high-risk genotypes. Establishment of a gray zone is recommended.

* Corresponding author. Mailing address: Institute of Microbiology and Immunology, Faculty of Medicine, Zaloska 4, 1000 Ljubljana, Slovenia. Phone: 386 1 543 7453. Fax: 386 1 543 7418. E-mail: mario.poljak{at}mf.uni-lj.si

{triangledown} Published ahead of print on 3 June 2009.

Journal of Clinical Microbiology, August 2009, p. 2611-2615, Vol. 47, No. 8
0095-1137/09/$08.00+0     doi:10.1128/JCM.00278-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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