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Journal of Clinical Microbiology, August 2009, p. 2639-2642, Vol. 47, No. 8
0095-1137/09/$08.00+0     doi:10.1128/JCM.00119-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Assessment of the Ability of a Fourth-Generation Immunoassay for Human Immunodeficiency Virus (HIV) Antibody and p24 Antigen To Detect both Acute and Recent HIV Infections in a High-Risk Setting {triangledown}

Mark W. Pandori,1* John Hackett Jr.,2 Brian Louie,1 Ana Vallari,2 Teri Dowling,1 Sally Liska,1 and Jeffrey D. Klausner1,3

San Francisco Department of Public Health, San Francisco, California,1 Abbott Diagnostics, Abbott Park, Illinois,2 University of California at San Francisco, San Francisco, California3

Received 20 January 2009/ Returned for modification 22 May 2009/ Accepted 7 June 2009

An immunoassay (IA) that simultaneously detects both antibody to human immunodeficiency virus (HIV) and HIV p24 antigen (Architect HIV Ag/Ab Combo) was evaluated for its ability to detect HIV infection by using a panel of specimens collected from individuals recently infected with HIV type 1 (HIV-1). This IA was found to be capable of detecting the majority (89%) of infections, including 80% of those considered acute infections based on the presence of HIV RNA and the lack of detectable antibody to HIV. Substantial improvements in detection of recent infections by the Architect HIV Ag/Ab Combo relative to previous generations of IAs as well as the capacity to detect acute infections have important implications for HIV prevention strategies.

* Corresponding author. Mailing address: San Francisco Department of Public Health, 101 Grove St., Room 412, San Francisco, CA 94102. Phone: (415) 554-2800. Fax: (415) 431-0651. E-mail: Mark_Pandori{at}sfdph.org

{triangledown} Published ahead of print on 17 June 2009.

Journal of Clinical Microbiology, August 2009, p. 2639-2642, Vol. 47, No. 8
0095-1137/09/$08.00+0     doi:10.1128/JCM.00119-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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