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Journal of Clinical Microbiology, September 2009, p. 2826-2833, Vol. 47, No. 9
0095-1137/09/$08.00+0     doi:10.1128/JCM.00507-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Epidemiology of Enterovirus 71 in The Netherlands, 1963 to 2008{triangledown}

Sabine van der Sanden,1,2* Marion Koopmans,1,2 Gökhan Uslu,1 Harrie van der Avoort,1 on behalf of the Dutch Working Group for Clinical Virology

National Institute for Public Health and the Environment, RIVM, Bilthoven, The Netherlands,1 Erasmus Medical Center, Department of Virology, Rotterdam, The Netherlands2

Received 12 March 2009/ Returned for modification 28 June 2009/ Accepted 14 July 2009

The incidence of enterovirus 71 (EV71) infection has greatly increased in the Asian Pacific region since 1997. Several large outbreaks, caused by different subgenogroups of EV71, occurred with high rates of morbidity and a substantial number of deaths. In 2007, 58 cases of EV71 infection requiring hospitalization were reported in The Netherlands after a period of low endemicity of 21 years. These events triggered a study on the epidemiology of EV71 in The Netherlands. Genetic analysis of the VP1 capsid region of 199 EV71 isolates collected from 1963 to 2008 as part of enterovirus surveillance activities revealed a change in the prevailing subgenogroups over time. From 1963 to 1986 infections were caused by three different and successive lineages belonging to subgenogroup B (the novel lineage designated B0, as well as B1 and B2). In 1987, following a major epidemic the previous year, the B genogroup was replaced by genogroup C strains of lineages C1 and, later, C2. Analyses of the clinical data suggested that there were differences between infection with genogroup B and with genogroup C strains in terms of the age groups affected and the severity of illness. From comparative analysis with genomic data available in the public domain, we concluded that EV71 strain evolution shows a global pattern, which leads to the question of whether the recently emerged C4 lineage strains will also spread outside of Asia.

* Corresponding author. Mailing address: National Institute for Public Health and the Environment, RIVM, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Phone: 31 30274 4073. Fax: 31 30274 4418. E-mail: sabine.van.der.sanden{at}rivm.nl

{triangledown} Published ahead of print on 22 July 2009.

Journal of Clinical Microbiology, September 2009, p. 2826-2833, Vol. 47, No. 9
0095-1137/09/$08.00+0     doi:10.1128/JCM.00507-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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