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Journal of Clinical Microbiology, September 2009, p. 3000-3003, Vol. 47, No. 9
0095-1137/09/$08.00+0     doi:10.1128/JCM.01119-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Cooccurrence of Predominant Panton-Valentine Leukocidin-Positive Sequence Type (ST) 152 and Multidrug-Resistant ST 241 Staphylococcus aureus Clones in Nigerian Hospitals{triangledown}

Kenneth O. Okon,1,3,{dagger} Patrick Basset,2,{dagger} Auwalu Uba,3 Johnson Lin,4 Bukola Oyawoye,3 Adebayo O. Shittu,5 and Dominique S. Blanc2*

Department of Medical Microbiology, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria,1 Service of Hospital Preventive Medicine, University Hospital, Lausanne, Switzerland,2 Department of Biological Sciences, Abubakar Tafawa Balewa University, Bauchi, Nigeria,3 School of Biochemistry, Genetics and Microbiology, University of KwaZulu-Natal, Durban, Republic of South Africa,4 Department of Microbiology, Obafemi Awolowo University, Ile-Ife, Nigeria5

Received 8 June 2009/ Returned for modification 8 July 2009/ Accepted 10 July 2009

Ninety-six clinical isolates of Staphylococcus aureus from Nigeria were characterized phenotypically and genetically. Twelve multidrug-resistant methicillin (meticillin)-resistant S. aureus (MRSA) isolates carrying a new staphylococcal cassette chromosome mec element and a high proportion of Panton-Valentine leukocidin (PVL)-positive methicillin-susceptible S. aureus (MSSA) isolates were observed. The cooccurrence of multidrug-resistant MRSA and PVL-positive MSSA isolates entails the risk of emergence of a multidrug-resistant PVL-positive MRSA clone.


* Corresponding author. Mailing address: Service of Hospital Preventive Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland. Phone: 41 21 314 02 59. Fax: 41 21 314 02 62. E-mail: Dominique.Blanc{at}chuv.ch

{triangledown} Published ahead of print on 15 July 2009.

{dagger} These authors contributed equally to this study.


Journal of Clinical Microbiology, September 2009, p. 3000-3003, Vol. 47, No. 9
0095-1137/09/$08.00+0     doi:10.1128/JCM.01119-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.