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Journal of Clinical Microbiology, September 2009, p. 3034-3037, Vol. 47, No. 9
0095-1137/09/$08.00+0     doi:10.1128/JCM.00561-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

CASE REPORT

First Description of NOD2 Variant Associated with Defective Neutrophil Responses in a Woman with Granulomatous Mastitis Related to Corynebacteria {triangledown}

Béatrice Bercot,1 Caroline Kannengiesser,2 Claire Oudin,2 Bernard Grandchamp,2 Marie-José Sanson-le Pors,1 Stéphane Mouly,3,{dagger} and Carole Elbim2,{dagger}*

AP-HP, Université Paris 7-Denis Diderot, Centre Hospitalier Universitaire Lariboisière-Fernand Widal, Service de Bactériologie-Virologie, Paris 10, France,1 AP-HP, Centre Hospitalier Universitaire Xavier Bichat, Service d'Immunologie et d'Hématologie et Service de Biochimie Hormonale et Génétique, CIB Phenogen, Paris F-75018, France,2 AP-HP, Université Paris 7-Denis Diderot, Centre Hospitalier Universitaire Lariboisière-Fernand Widal, Service de Médecine Interne, Group Hospitalier, Paris 10, France3

Received 19 March 2009/ Returned for modification 20 May 2009/ Accepted 10 June 2009

We report the first case of granulomatous mastitis due to Corynebacterium kroppenstedtii linked to strongly impaired neutrophil responses to Nod2 agonist and a single nucleotide polymorphism within the NOD2 gene (SNP13 [Leu1007fsinsC]) in a heterozygous state. These findings provided the first demonstration of impaired Nod2 function associated with corynebacterial infection.

* Corresponding author. Present address: UMRS 872, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France. Phone and fax: 33 1 42 34 68 93. E-mail: carole.elbim{at}crc.jussieu.fr

{triangledown} Published ahead of print on 29 July 2009.

{dagger} These two authors made equal contributions to this work.

Journal of Clinical Microbiology, September 2009, p. 3034-3037, Vol. 47, No. 9
0095-1137/09/$08.00+0     doi:10.1128/JCM.00561-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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