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Journal of Clinical Microbiology, September 2009, p. 3038-3040, Vol. 47, No. 9
0095-1137/09/$08.00+0     doi:10.1128/JCM.00772-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Two Cases of Mycobacterium microti-Induced Culture-Negative Tuberculosis{triangledown}

Eefje de Jong,1* Rob J. Rentenaar,1 Rob van Pelt,1 Wiel de Lange,3 Wim Schreurs,4 Dick van Soolingen,2 and Patrick D. J. Sturm1

Department of Medical Microbiology, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen,1 Tuberculosis Reference Laboratory, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands,2 University Lung Center Dekkerswald, Radboud University Nijmegen Medical Center, P.O. Box 66, 6561 KE Groesbeek, The Netherlands,3 Department of Orthopedic Surgery, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands4

Received 16 April 2009/ Returned for modification 7 May 2009/ Accepted 22 June 2009

We present descriptions of two human Mycobacterium microti infections: one of a patient with pulmonary disease and one of a patient with osteomyelitis of the hip. Both patients had acid-fast bacilli and a positive Mycobacterium tuberculosis complex PCR from clinical specimens, but mycobacterial cultures remained negative. The microbiological diagnosis was established by molecular methods.

* Corresponding author. Mailing address: Department of Medical Microbiology, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31 (0) 24 3619041. Fax: 31 (0) 243540216. E-mail: e.dejong{at}mmb.umcn.nl

{triangledown} Published ahead of print on 1 July 2009.

Journal of Clinical Microbiology, September 2009, p. 3038-3040, Vol. 47, No. 9
0095-1137/09/$08.00+0     doi:10.1128/JCM.00772-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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