JCM Antimicrobial Agents and Chemotherapy
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JCM Accepts, published online ahead of print on 16 April 2008
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J. Clin. Microbiol. doi:10.1128/JCM.00611-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Rapid MSSA-MRSA differentiation and MIC determinations by isothermal microcalorimetry

Ueli von Ah, Dieter Wirz, and A. U. Daniels*

Laboratory for Orthopaedic Biomechanics, Clinical Morphology & Biomedical Engineering, University Basel Faculty of Medicine

* To whom correspondence should be addressed. Email: au.daniels{at}unibas.ch.


  Abstract

In this study, the use of isothermal microcalorimetry (IMC) for MRSA-MSSA differentiation and MIC determination was evaluated. It was possible to differentiate between MRSA and MSSA within 4 h whereas the standard method required 24 h. The MIC of cefoxitin was successfully determined for MRSA and MSSA using IMC.




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