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J Clin Microbiol. 1975 June; 1(6): 500-503

Preparation of Rocky Mountain spotted fever vaccine suitable for human immunization.

R H Kenyon and C E Pedersen Jr

ABSTRACT

Rocky Mountain spotted fever vaccine was produced from rickettsiae grown in chicken embryo cells in roller bottle cultures. The rickettsiae were concentrated and purified by passage through a sucrose gradient and inactivated with formalin. This vaccine satisfactorily passed preinactivation and final container testing and is believed to be superior to the presently available yolk sac vaccine.

J Clin Microbiol. 1975 June; 1(6): 500-503




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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1975 by the American Society for Microbiology. All rights reserved.