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J Clin Microbiol. 1994 June; 32(6): 1604-1605
Animal Center for Biomedical Research, Faculty of Medicine, University of Tokyo, Japan.
ABSTRACT
We examined live virus vaccines against measles, mumps, and rubella for the presence of pestivirus RNA or of pestiviruses by reverse transcription PCR. Pestivirus RNA was detected in two measles-mumps-rubella combined vaccines and in two monovalent vaccines against mumps and rubella. Nucleotide sequence analysis of the PCR products indicated that a modified live vaccine strain used for immunization of cattle against bovine viral diarrhea is not responsible for the contamination of the vaccines.
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