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Journal of Clinical Microbiology, 01 1995, 209-211, Vol 33, No. 1
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Serological reactivity and viral genotypes in hepatitis C virus infection

F Maggi, ML Vatteroni, M Pistello, CM Avio, N Cecconi, F Panicucci and M Bendinelli
Virology Section, University of Pisa, Italy.

Patients infected with hepatitis C virus (HCV) were examined with four commercial HCV immunoblotting assays and for anti-GOR antibody to ascertain whether serological findings varied with the genotype of the infecting virus. The results indicate that patients infected with different HCV genotypes tend to show different immunoblotting profiles, mainly due to a low prevalence of antibodies to the viral region NS4 in patients infected with genotypes III and IV. Differences were more evident with second- than with third-generation assays. Patients infected with genotype IV exhibited a lower prevalence of anti-GOR antibody than patients infected with other genotypes.


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  • Zein, N. N. (2000). Clinical Significance of Hepatitis C Virus Genotypes. Clin. Microbiol. Rev. 13: 223-235 [Abstract] [Full Text]  
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