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Journal of Clinical Microbiology, 01 1995, 212-214, Vol 33, No. 1
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Quantitative analysis of syncytium-inducing and non-syncytium-inducing virus in patients infected with human immunodeficiency virus type 1

RW Shafer, E Aguiniga and TC Merigan
Center for AIDS Research, Stanford University School of Medicine, California 94305.

Among 75 consecutive human immunodeficiency virus type 1 (HIV-1)- infected patients with moderate and advanced immunosuppression, those harboring syncytium-inducing (SI) HIV-1 had a lower CD(4+)-cell count (145 versus 278 cells per microliter, P < 0.001) and 10-fold-higher virus titers than patients with non-SI HIV-1 (398 versus 39 infectious units per 10(6) CD4+ lymphocytes; P < 0.001). In patients with SI virus, the mean titer of SI virus, determined with a quantitative MT-2 cell assay, was 135 SI infectious units per 10(6) CD4+ lymphocytes. Virus titer correlated inversely with CD(4+)-cell count in patients with SI (r = -0.67) but not non-SI (r = -0.29) virus.