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Journal of Clinical Microbiology, Nov 1995, 3064-3067, Vol 33, No. 11
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Intestinal cytomegalovirus disease in immunocompromised patients may be ruled out by search for cytomegalovirus DNA in stool samples

D Michel, E Marre, W Hampl, J Roczkos, S Muller, B Hertenstein, P Kern, B Heymer, B Salzberger and K Arasteh
Abteilung Virologie, Universitatsklinik Ulm, Innere Medizin, Klinikum I, Universitat zu Koln, Germany.

Cytomegalovirus (CMV) PCR from stool specimens was adopted as a diagnostic tool for patients with suspected CMV colitis. After being established, the method was evaluated in 17 AIDS patients and 19 other immunocompromised patients by comparison of PCR results with clinical, histological, and microbiological or virological data. CMV PCR was positive in 4 symptomatic patients with proven CMV colitis and negative in 15 of 16 patients without characteristic histopathology. Neither CMV immunoglobulin G seropositivity nor intestinal symptoms alone were significantly associated with positive PCR results, but severe active systemic CMV infection may lead to a positive PCR. Absence of CMV DNA in stool samples may prove useful in ruling out CMV related colitis.

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