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Journal of Clinical Microbiology, Oct 1996, 2577-2584, Vol 34, No. 10
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Clinical isolates of Histoplasma capsulatum from Indianapolis, Indiana, have a recombining population structure

DA Carter, A Burt, JW Taylor, GL Koenig and TJ White
Roche Molecular Systems, Alameda, California 94501, USA. dcarter@angis.su

A sample of 30 clinical isolates of Histoplasma capsulatum was analyzed to determine (i) whether genetic exchange is important in the life cycle of this fungus and (ii) whether distinct subpopulations which correlate with disease severity or host immune status exist. Eleven biallelic molecular markers were developed, with the frequency of the least common allele at each molecular locus ranging from 10 to 50%. Every isolate had a different, unique multilocus genotype. Data analysis indicated that frequent recombination occurs within the Indianapolis, Ind., population. There were no associations between isolates from the immunocompromised population or from those with different clinical manifestations of histoplasmosis.


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