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Journal of Clinical Microbiology, 04 1996, 1020-1023, Vol 34, No. 4
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Immunoglobulin A-specific serodiagnosis of acute human cytomegalovirus infection by using recombinant viral antigens

R Vornhagen, W Hinderer, HH Sonneborn, G Bein, L Matter, TH The, G Jahn and B Plachter
Research Department, Biotest AG, Dreieich, Germany.

The immunoglobulin A-specific reactivities of recombinant viral proteins from nine different reading frames of human cytomegalovirus were evaluated in enzyme-linked immunosorbent assay experiments. Antigen fragments of reading frames pUL32, pUL44, and pUL57 were identified as preferable antigens for immunoglobulin A serodiagnosis. Application of autologous fusion proteins which combine these polypeptides may be useful especially for the early detection of acute secondary human cytomegalovirus infection.


This article has been cited by other articles:

  • Lang, D., Vornhagen, R., Rothe, M., Hinderer, W., Sonneborn, H.-H., Plachter, B. (2001). Cross-Reactivity of Epstein-Barr Virus-Specific Immunoglobulin M Antibodies with Cytomegalovirus Antigens Containing Glycine Homopolymers. CVI 8: 747-756 [Abstract] [Full Text]  


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