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Journal of Clinical Microbiology, Jul 1996, 1815-1818, Vol 34, No. 7
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Precore mutant of hepatitis B virus prevails in acute and chronic infections in an area in which hepatitis B is endemic

CM Chu, CT Yeh, CT Chiu, IS Sheen and YF Liaw
Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung Medical College, Taipei, Taiwan.

By using an amplification-created restriction site method, the precore TAG mutant of hepatitis B virus was detected in 6 (75%) of 8 acute fulminant hepatitis B patients, 7 (58%) of 12 acute self-limiting hepatitis B patients, 35 (81%) of 43 hepatitis B virus surface antigen carriers with fulminant hepatitis, and 42 (70%) of 60 hepatitis B virus surface antigen carriers with chronic hepatitis. The precore TAG mutant prevails in acute and chronic hepatitis B of various severity in this area where hepatitis B is endemic.


This article has been cited by other articles:

  • Imamura, T, Yokosuka, O, Kurihara, T, Kanda, T, Fukai, K, Imazeki, F, Saisho, H (2003). Distribution of hepatitis B viral genotypes and mutations in the core promoter and precore regions in acute forms of liver disease in patients from Chiba, Japan. Gut 52: 1630-1637 [Abstract] [Full Text]  
  • Chu, C.-M., Yeh, C.-T., Lee, C.-S., Sheen, I-S., Liaw, Y.-F. (2002). Precore Stop Mutant in HBeAg-Positive Patients with Chronic Hepatitis B: Clinical Characteristics and Correlation with the Course of HBeAg-to-Anti-HBe Seroconversion. J. Clin. Microbiol. 40: 16-21 [Abstract] [Full Text]  


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