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Journal of Clinical Microbiology, Jul 1996, 1854-1855, Vol 34, No. 7
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Infrequent detection of lipoarabinomannan antibodies in human immunodeficiency virus-associated mycobacterial disease. Swiss HIV Cohort Study

K Boggian, W Fierz and PL Vernazza
Department of Medicine, Kantonsspital, St. Gallen, Switzerland.

A commercially available test for the serologic diagnosis of tuberculosis was evaluated for its applicability in human immunodeficiency virus (HIV)-positive patients. Antibodies to lipoarabinomannan were detectable in sera from only 9 of 85 HIV- positive patients with a confirmed diagnosis of tuberculosis. Given the low degree of sensitivity of the assay with sera from HIV-infected patients, the study does not support the use of this serologic assay for the diagnosis of tuberculosis in HIV-infected patients.


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