This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guiyoule, A.
Right arrow Articles by Carniel, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guiyoule, A.
Right arrow Articles by Carniel, E.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, 11 1997, 2826-2833, Vol 35, No. 11
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Recent emergence of new variants of Yersinia pestis in Madagascar [In Process Citation]

A Guiyoule, B Rasoamanana, C Buchrieser, P Michel, S Chanteau and E Carniel
National Reference Laboratory, and WHO Collaborating Center for Yersinia, Institut Pasteur, Paris, France.

Yersinia pestis, the causative agent of plague, has been responsible for at least three pandemics. During the last pandemic, which started in Hong Kong in 1894, the microorganism colonized new, previously unscathed geographical areas where it has become well established. The aim of this longitudinal study was to investigate the genetic stability of Y. pestis strains introduced into a new environment just under a century ago and to follow the epidemiology of any new genetic variant detected. In the present study, 187 strains of Y. pestis isolated between 1939 and 1996 from different regions of Madagascar and responsible mainly for human cases of bubonic and pneumonic plague were studied. Our principal genotyping method was rRNA gene profiling (ribotyping), which has previously been shown to be an effective scheme for typing Y. pestis strains of different geographical origins. We report that all studied Y. pestis strains isolated in Madagascar before 1982 were of classical ribotype B, the ribotype attributed to the Y. pestis clone that spread around the world during the third pandemic. In 1982, 1983, and 1994, strains with new ribotypes, designated R, Q, and T, respectively, were isolated on the high-plateau region of the island. Analysis of other genotypic traits such as the NotI genomic restriction profiles and the EcoRV plasmid restriction profiles revealed that the new variants could also be distinguished by specific genomic and/or plasmid profiles. A follow-up of these new variants indicated that strains of ribotypes Q and R have become well established in their ecosystem and have a tendency to spread to new geographical areas and supplant the original classical strain.


This article has been cited by other articles:

  • Falcao, J. P., Falcao, D. P., Pitondo-Silva, A., Malaspina, A. C., Brocchi, M. (2006). Molecular typing and virulence markers of Yersinia enterocolitica strains from human, animal and food origins isolated between 1968 and 2000 in Brazil.. J Med Microbiol 55: 1539-1548 [Abstract] [Full Text]  
  • Galimand, M., Carniel, E., Courvalin, P. (2006). Resistance of Yersinia pestis to Antimicrobial Agents.. Antimicrob. Agents Chemother. 50: 3233-3236 [Full Text]  
  • Hill, J., Eyles, J. E., Elvin, S. J., Healey, G. D., Lukaszewski, R. A., Titball, R. W. (2006). Administration of Antibody to the Lung Protects Mice against Pneumonic Plague.. Infect. Immun. 74: 3068-3070 [Abstract] [Full Text]  
  • Voskressenskaya, E., Leclercq, A., Tseneva, G., Carniel, E. (2005). Evaluation of Ribotyping as a Tool for Molecular Typing of Yersinia pseudotuberculosis Strains of Worldwide Origin. J. Clin. Microbiol. 43: 6155-6160 [Abstract] [Full Text]  
  • Tong, Z., Zhou, D., Song, Y., Zhang, L., Pei, D., Han, Y., Pang, X., Li, M., Cui, B., Wang, J., Guo, Z., Qi, Z., Jin, L., Zhai, J., Du, Z., Wang, J., Wang, X., Yu, J., Wang, J., Huang, P., Yang, H., Yang, R. (2005). Pseudogene accumulation might promote the adaptive microevolution of Yersinia pestis. J Med Microbiol 54: 259-268 [Abstract] [Full Text]  
  • Lowell, J. L., Wagner, D. M., Atshabar, B., Antolin, M. F., Vogler, A. J., Keim, P., Chu, M. C., Gage, K. L. (2005). Identifying Sources of Human Exposure to Plague. J. Clin. Microbiol. 43: 650-656 [Abstract] [Full Text]  
  • Anisimov, A. P., Lindler, L. E., Pier, G. B. (2004). Intraspecific Diversity of Yersinia pestis. Clin. Microbiol. Rev. 17: 434-464 [Abstract] [Full Text]  
  • Hill, J., Copse, C., Leary, S., Stagg, A. J., Williamson, E. D., Titball, R. W. (2003). Synergistic Protection of Mice against Plague with Monoclonal Antibodies Specific for the F1 and V Antigens of Yersinia pestis. Infect. Immun. 71: 2234-2238 [Abstract] [Full Text]  
  • Wilde, C., Bachellier, S., Hofnung, M., Carniel, E., Clement, J.-M. (2002). Palindromic Unit-Independent Transposition of IS1397 in Yersinia pestis. J. Bacteriol. 184: 4739-4746 [Abstract] [Full Text]  
  • Deng, W., Burland, V., Plunkett III, G., Boutin, A., Mayhew, G. F., Liss, P., Perna, N. T., Rose, D. J., Mau, B., Zhou, S., Schwartz, D. C., Fetherston, J. D., Lindler, L. E., Brubaker, R. R., Plano, G. V., Straley, S. C., McDonough, K. A., Nilles, M. L., Matson, J. S., Blattner, F. R., Perry, R. D. (2002). Genome Sequence of Yersinia pestis KIM. J. Bacteriol. 184: 4601-4611 [Abstract] [Full Text]  
  • Radnedge, L., Agron, P. G., Worsham, P. L., Andersen, G. L. (2002). Genome plasticity in Yersinia pestis. Microbiology 148: 1687-1698 [Abstract] [Full Text]  
  • Huang, X.-Z., Chu, M. C., Engelthaler, D. M., Lindler, L. E. (2002). Genotyping of a Homogeneous Group of Yersinia pestis Strains Isolated in the United States. J. Clin. Microbiol. 40: 1164-1173 [Abstract] [Full Text]  
  • Motin, V. L., Georgescu, A. M., Elliott, J. M., Hu, P., Worsham, P. L., Ott, L. L., Slezak, T. R., Sokhansanj, B. A., Regala, W. M., Brubaker, R. R., Garcia, E. (2002). Genetic Variability of Yersinia pestis Isolates as Predicted by PCR-Based IS100 Genotyping and Analysis of Structural Genes Encoding Glycerol-3-Phosphate Dehydrogenase (glpD). J. Bacteriol. 184: 1019-1027 [Abstract] [Full Text]  
  • Leclercq, A., Guiyoule, A., El Lioui, M., Carniel, E., Decallonne, J. (2000). High Homogeneity of the Yersinia pestis Fatty Acid Composition. J. Clin. Microbiol. 38: 1545-1551 [Abstract] [Full Text]  
  • Achtman, M., Zurth, K., Morelli, G., Torrea, G., Guiyoule, A., Carniel, E. (1999). Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis. Proc. Natl. Acad. Sci. USA 96: 14043-14048 [Abstract] [Full Text]  
  • Bach, S., Buchrieser, C., Prentice, M., Guiyoule, A., Msadek, T., Carniel, E. (1999). The High-Pathogenicity Island of Yersinia enterocolitica Ye8081 Undergoes Low-Frequency Deletion but Not Precise Excision, Suggesting Recent Stabilization in the Genome. Infect. Immun. 67: 5091-5099 [Abstract] [Full Text]  
  • Buchrieser, C., Prentice, M., Carniel, E. (1998). The 102-Kilobase Unstable Region of Yersinia pestis Comprises a High-Pathogenicity Island Linked to a Pigmentation Segment Which Undergoes Internal Rearrangement. J. Bacteriol. 180: 2321-2329 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»