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Journal of Clinical Microbiology, Nov 1997, 2966-2968, Vol 35, No. 11
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Strains of glycopeptide-resistant Enterococcus faecium can alter their van genotypes during an outbreak [In Process Citation]

N Woodford, PR Chadwick, D Morrison and BD Cookson
Laboratory of Hospital Infection, Central Public Health Laboratory, London, United Kingdom. nwoodfor@phls.co.uk

Two isolates of Enterococcus faecium with VanA glycopeptide resistance were isolated during a hospital outbreak of E. faecium with plasmid- mediated VanB resistance. Both were found to be identical to the VanB outbreak strain by pulsed-field gel electrophoresis. The genotype of this strain changed from vanB to vanA through an intermediate isolate that contained both the vanA and vanB gene clusters on distinct plasmids.


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