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Journal of Clinical Microbiology, 02 1997, 495-498, Vol 35, No. 2
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

A modified Elek test for detection of toxigenic corynebacteria in the diagnostic laboratory

KH Engler, T Glushkevich, IK Mazurova, RC George and A Efstratiou
Respiratory and Systemic Infection Laboratory, Central Public Health Laboratory, London, United Kingdom.

The detection of toxigenicity among Corynebacterium diphtheriae and Corynebacterium ulcerans strains is the most important test for the microbiological diagnosis of diphtheria. Difficulties with current methods, in particular the Elek test, are well documented. We therefore describe a modified Elek test which provides an accurate result after only 16 h of incubation, in contrast to 48 h for the conventional test.


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