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Journal of Clinical Microbiology, 03 1997, 745-750, Vol 35, No. 3
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Genetic analysis of a meningococcal population based on polymorphism of the pilA-pilB locus: a molecular approach for meningococcal epidemiology

M Guibourdenche, D Giorgini, A Gueye, M Larribe, JY Riou and MK Taha
Unite des Neisseria, Institut Pasteur, Paris, France.

The genetic relationships between 88 meningococcal strains were analyzed by using the polymorphism of the pilA gene and the multilocus enzyme electrophoresis. While a good agreement was observed, correlation with antigenic formula (serogroup, serotype, and serosubtype) was incomplete. The inadequacy of serological classification alone in outbreak surveillance may be overcome by DNA- based approaches.


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